Targeting drug delivery within the suprachoroidal space
نویسندگان
چکیده
منابع مشابه
Suprachoroidal Drug Delivery: Unique New Observations.
Gu et al. use ultra-high resolution ocular coherence tomography (UHR-OCT) in the guinea pig eye model to evaluate suprachoroidal drug delivery using 10to 20-lL injections of either saline, indocyanine green (ICG), or triamcinolone acetate (TA). The authors have an elegantly designed study that measures the cross-sectional area of the suprachoroidal space (SCS) using these various injections at ...
متن کاملTargeted administration into the suprachoroidal space using a microneedle for drug delivery to the posterior segment of the eye.
PURPOSE This study seeks to determine the intraocular pharmacokinetics of molecules and particles injected into the suprachoroidal space of the rabbit eye in vivo using a hollow microneedle. METHODS Suprachoroidal injections of fluorescein and fluorescently tagged dextrans (40 and 250 kDa), bevacizumab, and polymeric particles (20 nm to 10 μm in diameter) were performed using microneedles in ...
متن کاملOcular Drug Delivery: Targeting the Posterior Segment
An inch or less. That is the short distance an ocular drug must travel to reach a target site at the back of the eye. Research has traveled a long way over the past 4 decades in efforts to make this inch-long journey more successful. Delivering ocular drugs to their target tissues often requires them to traverse the fatwater-fat structure of the corneal barrier, while ensuring minimum wastage t...
متن کاملOcular Drug Delivery: Targeting the Posterior Segment
One inch or less. That is the short distance an ocular drug must travel to reach a target site at the back of the eye. Research has come a long way over the past 4 decades in efforts to make this inch-long journey more successful. Delivering ocular drugs to their target tissues often requires them to traverse the fat-water-fat structure of the corneal barrier while ensuring minimum wastage thro...
متن کاملAb-Externo AAV-Mediated Gene Delivery to the Suprachoroidal Space Using a 250 Micron Flexible Microcatheter
BACKGROUND The current method of delivering gene replacement to the posterior segment of the eye involves a three-port pars plana vitrectomy followed by injection of the agent through a 37-gauge cannula, which is potentially wrought with retinal complications. In this paper we investigate the safety and efficacy of delivering adeno-associated viral (AAV) vector to the suprachoroidal space using...
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ژورنال
عنوان ژورنال: Drug Discovery Today
سال: 2019
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2019.03.027